A number of patients, in addition Trihexyphenidyl, also revealed postural-kinetic tremor (see "tremor" ), but the presence of intention tremor usually exclude Parkinson's disease.Currently, three main types of tremors, which is observed in Parkinson's disease.Tremor Type I is a classic shake the rest with a frequency of 4.6 Hz, which is sometimes accompanied by postural and kinetic tremor, having the same frequency and which is a continuation of it.Tremor type II is a more high-postural-kinetic tremor (6-9 Hz), which may prevail over the rest tremor, and sometimes appears before him, which makes differential diagnosis with essential tremor (see "tremor" ). In some such cases, the combination of the two disorders (essential tremor and Parkinson's disease).Tremor type III is a postural-kinetic tremor with a frequency of 4.9 Hz, detected in patients with akinetic-rigid form of Parkinson's disease. Postural instability with propulsion, retropulsiey, lateropulsiey, part of the fall is normally attached to a relatively late stage of the disease.In the neuropsychological status revealed Artane uses (bradifreniya), against which approximately 20-30% of patients with advanced disease develop dementia. Approximately 50% of patients show signs of Artane uses. In patients with Parkinson's disease there are other mental changes, including psychotic disorders, anxiety, obsessive-compulsive syndrome, apathy, negativism, etc. Many of them are amplified under the influence of Artane (see below).